Complement-Dependent Cytotoxicity

Preferred Label : Complement-Dependent Cytotoxicity;

NCIt definition : Activated by cell-surface bound antibody, by immune complexes, or by microbial membrane carbohydrate, Complement-Dependent Cytotoxicity involves complex cascades (classical or properdin pathway) of sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins that generate Membrane Attack Complex, which creates target cell pores and lysis.;

Details

Origin ID

C41572;

UMLS CUI

C1516743;

Currated CISMeF NLP mapping
- complement-dependent cytotoxicity [OBI concept]
- complement-dependent cytotoxicity [GO term]
See also inter- (CISMeF)
- Complement dependent cytotoxicity [LOINC method]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- complement-dependent cytotoxicity [GO term]
biological_process_has_initiator_chemical_or_drug
- Antigen [NCIt concept]
biological_process_involves_gene_product
- Complement Component C1q [NCIt concept]
- Complement Component C9 [NCIt concept]
- Membrane Attack Complex [NCIt concept]
biological_process_is_part_of_process
- Host Defense Mechanism [NCIt concept]
- Immunity [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- Apolizumab [NCIt concept]
- Dinutuximab [NCIt concept]
- Monoclonal Antibody L6 [NCIt concept]
process_involves_gene
- C9 Gene [NCIt concept]
- C9 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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