Membrane Attack Complex

Preferred Label : Membrane Attack Complex;

NCIt synonyms : MAC; Complement C5b-9 Complex; Membrane-Attack Complex; TCC; Terminal Complement Complex; C5b-6-7-8-9; C5b-9;

NCIt definition : A protein complex composed of five activated complement proteins that form a transmembrane pore in pathogen cell membranes. Formation of the complex is initiated by C5 convertase cleavage of complement C5 that yields C5b. C5b forms a complex with C6 and then C7; this initial complex has an exposed hydrophobic site that can insert into the pathogen's cell membrane. Then the trimeric C8 is recruited to the complex and the C5b-6-7-8 complex promotes the polymerization of 10-16 molecules of C9, which form the pore. If enough of these pores penetrate the cell membrane of the pathogen, the targeted cell will lyse and die.;

Details

Origin ID

C178567;

UMLS CUI

C5552697;

Automatic exact mappings (from CISMeF team)
- Active C5b6789 (substance) [SNOMED CT concept]
- C5B-9 [LOINC component]
- Cognitive Behavioral Therapy [MeSH Descriptor]
- Colobomatous microphthalmia [ORDO Disease]
- Complement membrane attack complex (C5b-C6-C7-C8-C9n) [LOINC component]
- Tarsal-carpal coalition syndrome [OMIM Phenotype]
- complement membrane attack complex [MeSH Descriptor]
- complementary therapies [MeSH Descriptor]
- craniocerebral trauma [MeSH Descriptor]
- membrane attack complex [GO term]
- mitochondrion-associated adherens complex [GO term]
- transitional cell carcinoma [Radlex concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_product_has_biochemical_function
- Complement Component Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement-Dependent Cytotoxicity [NCIt concept]
has_gene_product_element
- Complement Component C6 [NCIt concept]
- Complement Component C8 [NCIt concept]
- Complement Component C8 Alpha Chain [NCIt concept]
- Complement Component C8 Beta Chain [NCIt concept]
- Complement Component C8 Gamma Chain [NCIt concept]
- Complement Component C9 [NCIt concept]

Keyword's position in hierarchy(ies) :

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