complement membrane attack complex

Preferred Label : complement membrane attack complex;

MeSH definition : A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the membrane attack complex or MAC.;

MeSH synonym : c5b 8 poly c9; complement complex c5b-9; c5b-8-poly-c9; terminal complement complex; complement complex, terminal; complex, terminal complement; complement complex c5b 9; cytolytic terminal complement complex; membrane attack complex; c 5b-9; c5b-9;

MeSH annotation : DF: COMPLEMENT MAC;

Wikipedia link : https://en.wikipedia.org/wiki/Complement membrane attack complex;

Is substance : O;

Details

Origin ID

D015938;

UMLS CUI

C0009545;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Complement C5b-9 Measurement [NCIt concept]
- Complement membrane attack complex (C5b-C6-C7-C8-C9n) [LOINC component]
- Membrane Attack Complex [NCIt concept]
- membrane attack complex [GO term]
Currated CISMeF NLP mapping
- Active C5b6789 (substance) [SNOMED CT concept]
- C5B-9 [LOINC component]
- Complement Sc5b-9 [LOINC component]
- active c5b6789 [SNOMED Notion]
Indexing information
- S-protein (control) [MeSH Supplementary Concept]
- complement C9 polymer [MeSH Supplementary Concept]
Pharmacological action(s)
- immunologic factors [MeSH Descriptor]
Record concept(s)
- complement membrane attack complex [MeSH concept]
Related MeSH Supplementary Concept(s)
- SC5b-9 protein complex [MeSH Supplementary Concept]
See also
- cytotoxicity, immunologic [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Active C5b6789 (substance) [SNOMED CT concept]
- C5B-9 [LOINC component]
- Complement C5b-9 Measurement [NCIt concept]
- Complement Sc5b-9 [LOINC component]
- Complement membrane attack complex (C5b-C6-C7-C8-C9n) [LOINC component]
- active c5b6789 [SNOMED Notion]

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