NCIt related terms : Ch14.18; monoclonal antibody Ch14.18; MOAB Ch14.18;
NCIt definition : A chimeric mouse/human monoclonal antibody with potential antineoplastic activity.
Dinutuximab binds to the ganglioside GD2 and induces antibody-dependent cell-mediated
cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells.
GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small
cell carcinoma of the lung.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It binds to a molecule
called GD2, which is found in greater than normal amounts on some types of cancer
cells. This helps cells of the immune system kill the cancer cells. It is a type of
monoclonal antibody.;
UNII : 7SQY4ZUD30;
CAS number : 1363687-32-4;
Drug name : Unituxin; Qarziba;
Molecule name : Ch14.18;
NSC code : 623408;
Codes from synonyms : CDR0000665424; CDR0000665426; CDR0000665425; 161;