Preferred Label : Ganglioside GD2;
NCIt synonyms : GD2 Ganglioside; GalNAc(beta 1- 4)-[NeuAc(alpha 2- 8)NeuAc(alpha 2- 3)]Gal(beta 1- 4)GlcCer; GD2; Ganglioside, GD2;
NCIt related terms : DISIALOGANGLIOSIDE GD-2;
NCIt definition : A cell surface antigen expressed on all tumors of neuroectodermal origin, including
melanoma, neuroblastomas, sarcoma, astrocytomas, and small cell lung cancer. GD2,
an O-acetylated disialoganglioside, belongs to the group of glycosphingolipids that
are widely expressed in many tissues and organs in vertebrates and have been suggested
to be involved in the regulation of development and differentiation as recognition
molecules or signal modulators. Due to its high level of expression in neuroblastoma,
GD2 has the potential to be used as a component of anti-neuroblastoma vaccines, in
addition to being used in polyvalent anti-melanoma vaccines.;
Alternative definition : CDISC: A sialic acid-containing glycosphingolipid antigen and a component of the cell
plasma membrane that modulates cell signal transduction, with a designation of GD2.
It can be considered as an autoantigen and is commonly associated with autoimmune
neuropathies such as Guillain-Barre syndrome and multiple sclerosis.;
UNII : FUI2V09E1C;
CAS number : 65988-71-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 65988-71-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Origin ID : C1110;
UMLS CUI : C0061104;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_target
