Preferred Label : Pentavalent KLH Conjugate Vaccine;
NCIt definition : A pentavalent vaccine comprised of the epitope antigens of the ganglioside lactones
GD2L and GD3L, Globo H hexasaccharide 1 (Globo H), fucosyl GM1 and N-propionylated
polysialic acid conjugated with the immunostimulant keyhole limpet hemocyanin (KLH),
with potential immunostimulating and antineoplastic activity. Vaccination with the
pentavalent KLH conjugate vaccine may induce production of IgG and IgM antibodies
as well as an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumors
expressing any of these antigens. The antigens included in the pentavalent KLH conjugate
vaccine are upregulated in a variety of cancer cells. KLH, a natural protein isolated
from the marine mollusk keyhole limpet, is an immunostimulant carrier protein.;
NCI Metathesaurus CUI : CL429641;
Origin ID : C97034;
UMLS CUI : C3273203;
Semantic type(s)
- concept_is_in_subset
- has_target
