" /> Ganglioside GD3 - CISMeF





Preferred Label : Ganglioside GD3;

NCIt synonyms : Disialosyllactosylceramide; GD3 ganglioside; N-Acetylneuraminyl N-acetylneuraminylgalactosylglucosylceramide;

NCIt definition : A cell surface antigen expressed on all tumors of neuroectodermal origin, including melanoma, neuroblastomas, sarcoma, astrocytomas, and small cell lung cancer. GD3, an O-acetylated disialoganglioside, belongs to the group of glycosphingolipids that are widely expressed in many tissues and organs in vertebrates and have been suggested to be involved in the regulation of development and differentiation as recognition molecules or signal modulators. GD3 and GD2 gangliosides represent distinct and relevant immunotherapeutic target structures on melanoma, thereby both have the potential to be used as components of anti-melanoma vaccines.;

Alternative definition : CDISC: A sialic acid-containing glycosphingolipid antigen and a component of the cell plasma membrane that modulates cell signal transduction, with a designation of GD3. It can be considered as an autoantigen and is commonly associated with autoimmune neuropathies such as Guillain-Barre syndrome and multiple sclerosis.;

CAS number : 62010-37-1;

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06/05/2025


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