Preferred Label : GD2 Lactone/GD3 Lactone-KLH Conjugate Bivalent Vaccine;
NCIt synonyms : GD2 Lactone GD3 Lactone-KLH Conjugate Bivalent Vaccine;
NCIt definition : A cancer vaccine, containing epitopes of the gangliosides GD2 and GD3 conjugated with
the immunostimulant keyhole limpet hemocyanin (KLH), with potential antineoplastic
activity. Vaccination with GD2 lactone/GD3 lactone-KLH conjugate bivalent vaccine
may elicit antibodies against tumor cells expressing either epitope, resulting in
complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity
(ADCC). Located primarily in the nervous system, gangliosides, such as GD2 and GD3,
are cell membrane components involved in cellular recognition and cell-cell communication.;
NCI Metathesaurus CUI : CL383507;
Origin ID : C74035;
UMLS CUI : C2348719;
Semantic type(s)
- concept_is_in_subset
- has_target
