Preferred Label : GM2/GD2/GD3 Lactone-KLH Conjugate Trivalent Vaccine;
NCIt definition : A trivalent cancer vaccine containing the ganglioside lactones GM2, GD2 and GD3 conjugated
with the immunostimulant keyhole limpet hemocyanin (KLH), with potential antineoplastic
activity. Vaccination with GM2 lactone/GD2 lactone/GD3 lactone-KLH conjugate trivalent
vaccine may elicit antibodies against tumor cells expressing any of these epitopes,
resulting in an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor
cells expressing these gangliosides. GM2, GD2 and GD3 are tumor associated antigens
(TAAs) that are overexpressed in a variety of tumor cell membranes.;
NCI Metathesaurus CUI : CL421633;
Origin ID : C91377;
UMLS CUI : C2984199;
Semantic type(s)
- concept_is_in_subset
- has_target
