Ganglioside GM2

Preferred Label : Ganglioside GM2;

NCIt synonyms : GM2 ganglioside;

NCIt definition : A glycosphingolipid antigen expressed by a variety of human cancer cells. GM2 containing vaccines have been shown to elicit antibodies production in melanoma patients without deleterious effects associated with an immune response to GM2. Mutations in at least 1 of 3 recessive genes: HEXA, HEXB, and GM2A cause defects in GM2 catabolism, leading to lysosomal lipid storage disorders that manifest primarily as neurodegenerative diseases, including Tay-Sachs and Sandhoff Disease.;

Alternative definition : CDISC: A sialic acid-containing glycosphingolipid antigen and a component of the cell plasma membrane that modulates cell signal transduction, with a designation of GM2. It can be considered as an autoantigen and is commonly associated with autoimmune neuropathies such as Guillain-Barre syndrome and multiple sclerosis.;

CAS number : 19600-01-2;

Details

Origin ID

C516;

UMLS CUI

C0016896;

Automatic exact mappings (from CISMeF team)
- Ganglioside GM2 [LOINC component]
Currated CISMeF NLP mapping
- G(M2) ganglioside [MeSH concept]
- Ganglioside GM>2< (substance) [SNOMED CT concept]
- g(m2) ganglioside [MeSH Descriptor]
- ganglioside gm2, nos [SNOMED Notion]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- G(M2) ganglioside [MeSH concept]
- Ganglioside GM2 [LOINC component]
- Ganglioside GM2 [LOINC part]
- Ganglioside GM>2< (substance) [SNOMED CT concept]
- g(m2) ganglioside [MeSH Descriptor]
- ganglioside gm2, nos [SNOMED Notion]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_target
- Anti-Ganglioside GM2 Monoclonal Antibody BIW-8962 [NCIt concept]
- GM2-KLH Vaccine [NCIt concept]
- GM2/GD2/GD3 Lactone-KLH Conjugate Trivalent Vaccine [NCIt concept]
- Globo-H-GM2-Lewis-y-MUC1-32(aa)-sTn(c)-TF(c)-Tn(c)-KLH Conjugate Vaccine [NCIt concept]
- Polyvalent Antigen-KLH Conjugate Vaccine [NCIt concept]

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