Preferred Label : Polyvalent Antigen-KLH Conjugate Vaccine;
NCIt definition : A multivalent cancer vaccine comprised of the five tumor-associated antigens (TAAs)
globo H, GM2 ganglioside, Tn-MUC1, TF, and sTn conjugated with the immunoadjuvant
keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Upon administration,
polyvalent antigen-KLH conjugate vaccine may induce production of IgG and IgM antibodies
and antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing
these TAAs, resulting in tumor cell death and tumor growth inhibition. Globo H (globo
H hexasaccharide 1); GM2 ganglioside; Tn-MUC1 (human tumor-associated epithelial mucin
1 carrying the tumor-specific glycan Tn); TF (Thompson-Friedreich); and sTn (sialyl-Tn)
are overexpressed in a variety of cancer cells. KLH is a hapten carrier and serves
as an immunostimulant to improve immune recognition of antigens.;
NCI Metathesaurus CUI : CL387032;
Origin ID : C77870;
UMLS CUI : C2698849;
Semantic type(s)
- concept_is_in_subset
- has_target
