Preferred Label : Sialyl Tn Antigen;
NCIt synonyms : Sialyl-Tn Antigen; STn Antigen; STn; CD175s; Sialyl-Tn;
NCIt definition : A tumor-associated core-region carbohydrate antigen of epithelial mucin, expressed
in most colon carcinoma, mucinous carcinoma, pancreatic cancer, gastric, lung, breast,
and ovarian carcinoma. Sialosyl-Tn (STn) antigen has been shown to be highly sensitive
and a specific marker of colorectal cancer, associated with more aggressive diseases
and poor prognosis. STn antigen and its immediate precursor, Tn antigen, are mucin
type glycoprotein structures associated with the earliest steps of mucin O-linked
glycosylation. When combined with a carrier molecule, keyhole limpet hemocyanin (KLH),
this antigen may be co-administered with oral cyclophosphamide as an immune modulator.;
Origin ID : C1226;
UMLS CUI : C0074480;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
- is_target
