Preferred Label : Anti-STn Antibody-drug Conjugate SGN-STNV;
NCIt synonyms : Anti-STn ADC SGN-STNV; Anti-STn Vedotin ADC SGN-STNV; ADC SGN-STNV; Anti-Sialyl Thomsen-nouveau Antibody-drug Conjugate SGN-STNV;
NCIt definition : An antibody-drug conjugate (ADC) composed of an antibody directed against the tumor-associated
carbohydrate antigen Sialyl Thomsen-nouveau (STn) conjugated to the cytotoxic agent
monomethyl auristatin E (MMAE) via the MC-vc-PAB linker, with potential antineoplastic
activity. Upon administration of the anti-STn ADC SGN-STNV, the anti-STn antibody
targets and binds to STn expressed on tumor cells. Following internalization of SGN-STNV
and release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization.
This results in G2/M phase cell cycle arrest and apoptosis in STn-expressing tumor
cells. STn, a tumor-associated carbohydrate antigen that is present on various tumor-associated
glycoproteins including CA-125 and mucin-1 (MUC1), is expressed in multiple tumor
types.;
Molecule name : SGN-STNV; SGN STNV;
NCI Metathesaurus CUI : CL1648330;
Origin ID : C178706;
UMLS CUI : C5555198;
Semantic type(s)
- concept_is_in_subset
- has_target
