Sialyl Tn-KLH Vaccine

Preferred Label : Sialyl Tn-KLH Vaccine;

NCIt synonyms : Sialyl Tn-KLH; STn-KLH Vaccine; Theratope siayl-Tn-KLH vaccine; Theratope STn-KLH Vaccine; Theratope Vaccine;

NCIt definition : A vaccine containing a pancarcinoma carbohydrate antigen conjugated with keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Sialylated Tn antigen (sTn) is a monosaccharide glycan usually O-linked to serine or threonine residues of mucins found on most epithelial cancers. Conjugation with KLH, a hapten carrier and an immunostimulant, improves host immune responses. Vaccination with sTn-KLH vaccine may produce antibodies and elicit a cytotoxic T lymphocyte (CTL) response against those tumor cells expressing sTn, resulting in decreased tumor growth.;

Alternative definition : NCI-GLOSS: A vaccine composed of a substance that enhances immunity plus an antigen found on some tumors of the colon, breast, lung, ovary, pancreas, and stomach.;

Drug name : Theratope;

Codes from synonyms : CDR0000045879;

Détails

Origin ID

C1690;

UMLS CUI

C0388828;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- sialyl-Tn antigen-keyhole-limpet hemocyanin conjugate [MeSH Supplementary Concept]
- sialyl-Tn antigen-keyhole-limpet hemocyanin conjugate [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Sialyl Tn Antigen [NCIt concept]
is_component_of_chemotherapy_regimen
- Cyclophosphamide/Theratope STn-KLH Vaccine [NCIt concept]

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