NCIt definition : A vaccine containing a pancarcinoma carbohydrate antigen conjugated with keyhole limpet
hemocyanin (KLH), with potential antineoplastic activity. Sialylated Tn antigen (sTn)
is a monosaccharide glycan usually O-linked to serine or threonine residues of mucins
found on most epithelial cancers. Conjugation with KLH, a hapten carrier and an immunostimulant,
improves host immune responses. Vaccination with sTn-KLH vaccine may produce antibodies
and elicit a cytotoxic T lymphocyte (CTL) response against those tumor cells expressing
sTn, resulting in decreased tumor growth.;
Alternative definition : NCI-GLOSS: A vaccine composed of a substance that enhances immunity plus an antigen
found on some tumors of the colon, breast, lung, ovary, pancreas, and stomach.;