Thomsen-Friedenreich Antigen

Preferred Label : Thomsen-Friedenreich Antigen;

NCIt synonyms : Antigen, Thomsen-Friedenreich; TF(c); Thompson-Friedenreich Antigen;

NCIt definition : A type 1 core O-glycan with potential immunotherapeutic property. Thomsen-Friedenreich (TF) antigen, a galactose disaccharide, is normally O-linked to serine or threonine residue of mucins (MUC1), a transmembrane glycoprotein overexpressed on epithelial cell surface of a variety of tumor cells. The expression of this antigen is associated with tumor cell adhesion, tissue invasion and aggressiveness. When administered in a vaccine formulation, TF antigen may stimulate a cytotoxic T cell response against tumors expressing TF epitope, which may result in a reduction in tumor size.;

Details

Origin ID

C2528;

UMLS CUI

C0053438;

Automatic exact mappings (from CISMeF team)
- transferrin [MeSH Descriptor]
- transferrins [Substance BNPC]
Currated CISMeF NLP mapping
- Thomsen-Friedenreich antigen [MeSH concept]
- Thomsen-Friedenreich antigen [MeSH Supplementary Concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Thomsen-Friedenreich antigen [MeSH concept]
- Thomsen-Friedenreich antigen [MeSH Supplementary Concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
is_target
- Globo-H-GM2-Lewis-y-MUC1-32(aa)-sTn(c)-TF(c)-Tn(c)-KLH Conjugate Vaccine [NCIt concept]
- Polyvalent Antigen-KLH Conjugate Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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