" /> Mucin-1 - CISMeF





Preferred Label : Mucin-1;

NCIt synonyms : MUC1; CD227 Antigen; EMA; DF3 Antigen; Peanut-Reactive Urinary Mucin; PEMT; Episialin; PUM; H23 Antigen; Transmembrane Mucin 1; Breast Carcinoma-Associated Antigen DF3; H23AG; Tumor-Associated Mucin; Polymorphic Epithelial Mucin; Tumor-Associated Epithelial Membrane Antigen; PEM; Carcinoma-Associated Mucin; Mucin; Epithelial Membrane Antigen; CD227; Cancer Antigen 27.29; CA 27-29; MUC-1; Cancer Antigen 15-3; Mucin 1; CA 15-3; CA 27.29; KL-6; Krebs von den Lungen-6;

CISMeF synonym : CD227;

CISMeF acronym : MUC1;

NCIt definition : Mucin-1 (1255 aa, 122 kDa) is encoded by the human MUC1 gene. This protein plays a role in both signaling and cell adhesion.;

NCIt note : Mucin-1 is a type I membrane protein (major form) containing a large extracellular tandem repeat domain and a SEA domain. The number of repeats is highly polymorphic. This protein is expressed as at least 10 isoforms produced by alternative splicing. Isoforms 5 and 9 are secreted. Isoform 7 behaves as a receptor and binds isoform 5; binding induces phosphorylation of isoform 7, alters cell morphology, and initiates cell signaling. Cleaved isoform 1 forms a heterodimer with its secreted C-terminal peptide. Isoforms 1 and 7 are transphosphorylated on serine and tyrosine residues.; Mucin-1 is cleaved into Mucin-1 subunit alpha (MUC1-NT or MUC1-alpha) and Mucin-1 subunit beta (MUC1-beta or MUC1-CT). (UniProt);

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16/05/2024


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