Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells - CISMeF
Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cellsNCIt concept
Preferred Label : Autologous Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells;
NCIt synonyms : Autologous T-lymphocytes Expressing GD2-specific Chimeric Antigen and Constitutively
Active IL-7 Receptors; Autologous C7R-GD2.CART Cells; Constitutively Active IL-7 Receptor Co-expressing GD2-specific CAR T-cells;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen
(TAA) GD2, and the constitutively active interleukin 7 (IL-7) receptor (C7R), with
potential antineoplastic activity. Upon intravenous administration, autologous active
IL-7 receptor co-expressing GD2-specific CAR T-cells target, bind to, and induce selective
toxicity in GD2-expressing tumor cells. C7R triggers IL-7-mediated signaling that
promotes T-cell proliferation, survival, and anti-tumor activity. GD2, a disialoganglioside
and TAA, is overexpressed in a variety of tumor cell types.;