NCIt definition : A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation
chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs)
disialoganglioside (GD2) and CD56 (neural cell adhesion molecule 1; NCAM-1), with
potential immunostimulating and antineoplastic activities. Upon administration, the
anti-GD2/anti-CD56 4SCAR-expressing bispecific T-cells are directed to and induce
selective toxicity in GD2- and CD56-expressing tumor cells. GD2 is overexpressed on
the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while
it is minimally expressed on normal cells. CD56 is overexpressed on the surface of
various types of cancer cells, including small cell lung cancer (SCLC) and other neuroendocrine
tumors (NETs).;