NCIt definition : A monoclonal antibody directed against the tumor-associated antigen (TAA) disialoganglioside
(GD2; GD-2), with potential antineoplastic activity. Upon administration, donitabart
may induce cytotoxicity in GD2-expressing tumor cells by antibody-dependent cell-mediated
cytotoxicity (ADCC). GD2 is overexpressed on the surface of neuroblastoma (NB) cells
and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal
cells.;
Semantic type(s)