Preferred Label : Anti-GD2 Monoclonal Antibody BCD-245;
NCIt synonyms : Anti-GD-2 Monoclonal Antibody BCD-245;
NCIt definition : A monoclonal antibody directed against the tumor-associated antigen (TAA) disialoganglioside
(GD2; GD-2), with potential antineoplastic activity. Upon administration, anti-GD2
monoclonal antibody BCD-245 may induce cytotoxicity in GD2-expressing tumor cells
by antibody-dependent cell-mediated cytotoxicity (ADCC). GD2 is overexpressed on the
surface of neuroblastoma (NB) cells and by other neuroectoderm-derived neoplasms,
while it is minimally expressed on normal cells.;
Molecule name : BCD-245; BCD 245;
NCI Metathesaurus CUI : CL1907084;
Origin ID : C200262;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
