Preferred Label : Autologous Anti-GD2CAR-CD28-CD3zeta-IL-15-expressing Natural Killer T-cells;
NCIt synonyms : Autologous Anti-GD2CAR-CD28-CD3zeta-IL-15-expressing NKTs; G28z.15 NKTs;
NCIt related terms : Autologous Anti-GD2CAR-CD28-CD3zeta-IL-15-expressing;
NCIt definition : A preparation of autologous natural killer T-lymphocytes (NKTs) that have been transduced
with a retroviral vector to express both an extracellular domain consisting of interleukin
15 (IL-15) and a chimeric antigen receptor (CAR) specific for the human tumor associated
antigen (TAA) GD2, linked to the CD28 and CD3zeta (TCRzeta; CD247) costimulatory signaling
domains, with potential antineoplastic activity. Upon intravenous administration,
autologous anti-GD2CAR-CD28-CD3zeta-IL-15-expressing NKTs target, bind to, and induce
selective toxicity in GD2-expressing tumor cells. IL-15 is a pro-survival cytokine
that promotes T-cell persistence and potentiates the immune response against tumor
cells. Incorporation of the costimulatory signaling domains increases T-cell function,
expansion, and survival. The CD28 costimulatory molecule signaling domain enhances
activation and signaling after recognition of GD2. Additionally, inclusion of the
CD28 signaling domain may increase proliferation of T-cells and antitumor activity
compared to the inclusion of the CD3zeta chain alone. GD2, a disialoganglioside and
tumor-associated antigen (TAA), is overexpressed in a variety of tumor cell types.;
NCI Metathesaurus CUI : CL950772;
Origin ID : C158682;
UMLS CUI : C5203880;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
