Preferred Label : iC9-GD2-CD28-OX40-expressing T Lymphocytes;
NCIt synonyms : iC9-GD2 T Lymphocytes;
NCIt definition : Modified T-lymphocytes expressing a 3rd generation chimeric antigen receptor (CAR)
specific for the disialoganglioside GD2, which contains the CD3zeta chain, the signaling
domains of the co-stimulatory molecules CD28 and CD134 (OX-40) and the suicide gene
inducible caspase 9 (iCasp9), with potential immunomodulating and antineoplastic activities.
Upon administration, iC9-GD2-CD28-OX40-expressing T lymphocytes target the GD2 antigen
on tumor cells, thereby providing selective toxicity towards GD2-expressing tumor
cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation
(FKBP12-F36V) linked to human caspase 9. If the administered T cells lead to unacceptable
side effects, the chemical homodimerizer AP1903 can be administered, which binds to
the drug binding FKBP12-F36V domain and activates caspase 9, resulting in the apoptosis
of the administered T-cells. The tumor associated antigen GD2 is overexpressed on
the surface of almost all tumors of neuroectodermal origin. OX40 and CD28, both T-cell
surface-associated co-stimulatory molecules, are required for full T-cell activation.;
NCI Metathesaurus CUI : CL447359;
Origin ID : C106123;
UMLS CUI : C3829574;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
