Iodine I 124 Monoclonal Antibody 3F8

Preferred Label : Iodine I 124 Monoclonal Antibody 3F8;

NCIt synonyms : I 124 Monoclonal Antibody 3F8; 124I-hu3F8; 124 mAb 3F8; 124I-Humanized 3F8;

NCIt definition : A radioimmunoconjugate consisting of 3F8, a murine anti-GD2 ganglioside monoclonal antibody labeled with iodine I 124 (I-124), with radioimaging activity using positron emission tomography (PET). Upon intravenous administration of iodine I 124 monoclonal antibody 3F8, the 3F8 moiety binds to GD2 expressed on tumor cells. This binding enables both PET imaging via iodine I 124 and the visualization of GD2-expressing tumor cells. GD2 is a ganglioside overexpressed in a variety of cancer cells, including neuroblastoma cells.;

Details

Origin ID

C119749;

UMLS CUI

C3896574;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Ganglioside GD2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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