Naxitamab - CISMeF

Preferred Label : Naxitamab;

NCIt synonyms : Hu3F8; Humanized Anti-GD2 Antibody 3F8; Anti-Gd2 IGG3 Monoclonal Antibody 3f8 Humanized; Humanized Monoclonal Antibody Hu3f8-IGG1; Naxitamab-gqgk;

NCIt definition : A humanized monoclonal antibody directed against the human tumor-associated antigen GD2, with potential antineoplastic activity. Upon vaccination, naxitamab stimulates antibody-dependent cell-mediated cytotoxicity (ADCC) against GD2-expressing tumor cells. GD2, a disialoganglioside with expression in normal tissues restricted primarily to the cerebellum and peripheral nerves, is commonly expressed at high levels on tumors of neuroectodermal origins such as melanomas and neuroblastomas. Compared to the murine monoclonal antibody 3F8 (m3F8), the humanized form does not cause a human anti-mouse antibody (HAMA) response and shows enhanced ADCC activity.;

UNII : 9K8GNJ2874;

CAS number : 1879925-92-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1879925-92-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Danyelza;

Codes from synonyms : 26950;

Details

Origin ID

C123428;

UMLS CUI

C4733494;

Automatic exact mappings (from CISMeF team)
- HU3F8 [MeSH concept]
- naxitamab-gqgk [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Naxitamab (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Naxitamab (substance) [SNOMED CT concept]
- Product containing naxitamab (medicinal product) [SNOMED CT concept]
- naxitamab [ATC Code]
Validated automatic mappings to BTNT
- naxitamab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Ganglioside GD2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Naxitamab Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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