" /> Autologous Anti-GD2/Anti-PSMA 4SCAR-expressing Bispecific T-cells - CISMeF





Preferred Label : Autologous Anti-GD2/Anti-PSMA 4SCAR-expressing Bispecific T-cells;

NCIt synonyms : Autologous GD2/PSMA Bispecific 4SCAR-T Cells; Autologous Anti-GD2/PSMA Bispecific 4SCAR-T Cells; Autologous Anti-GD2/PSMA Bispecific 4SCAR-expressing T-cells; Autologous Bi-4SCAR GD2/PSMA T Cells; Autologous Anti-PSMA/Anti-GD2 4SCAR-expressing Bispecific T-cells;

NCIt definition : A preparation of autologous T-lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) disialoganglioside (GD2) and prostate-specific membrane antigen (PSMA), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-GD2/anti-PSMA 4SCAR-expressing bispecific T-cells are directed to and induce selective toxicity in GD2- and PSMA-expressing tumor cells. GD2 is overexpressed on the surface of neuroblastoma (NB) cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors, including brain tumor, NB and some lymphoma tumor tissues.;

NCI Metathesaurus CUI : CL1794073;

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14/05/2024


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