Glutamate Carboxypeptidase 2

Preferred Label : Glutamate Carboxypeptidase 2;

NCIt synonyms : GCP2; Glutamate Carboxypeptidase II; Prostate-Specific Membrane Antigen; PSMA; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; mGCP; NAALADase I; Cell Growth-Inhibiting Gene 27 Protein; Membrane Glutamate Carboxypeptidase; FGCP; PSM; Folylpoly-Gamma-Glutamate Carboxypeptidase; GCPII; Folate Hydrolase 1; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; EC 3.4.17.21; Folate Hydrolase-1; FOLH1;

NCIt definition : Glutamate carboxypeptidase 2 (750 aa, 84 kDa) is encoded by the human FOLH1 gene. This protein plays a role in the mediation of folate metabolism.;

Details

Origin ID

C17796;

UMLS CUI

C1310550;

Currated CISMeF NLP mapping
- glutamate carboxypeptidase II [MeSH concept]
- glutamate carboxypeptidase ii [MeSH Descriptor]
False automatic mappings
- Glutamate carboxypeptidase II (substance) [SNOMED CT concept]
OMIM relation
- Folate hydrolase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- FOLH1 protein, human [MeSH concept]
- FOLH1 protein, human [MeSH Supplementary Concept]
- Pteroylpoly-gamma-glutamate carboxypeptidase (substance) [SNOMED CT concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- FOLH1 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
- Tumor-Associated Vasculature [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
- Tumor Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Folic Acid Metabolic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Proteolysis [NCIt concept]
- Transport Process [NCIt concept]
is_target
- 99mTc-based PSMA Imaging and Surgery Agent [NCIt concept]
- Acapatamab [NCIt concept]
- Actinium Ac 225 PSMA-I&T [NCIt concept]
- Actinium Ac-225 Anti-PSMA Monoclonal Antibody J591 [NCIt concept]
- AdC68 Expressing PSA/PSMA/PSCA Vaccine PF-06755992 [NCIt concept]
- Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201 [NCIt concept]
- Anti-GD2/PSMA/CD276 4SCAR-expressing T-cells [NCIt concept]
- Anti-PSMA Antibody-drug Conjugate ARX517 [NCIt concept]
- Anti-PSMA Gamma Delta T-cell Engaging Bispecific Antibody LAVA-1207 [NCIt concept]
- Anti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704 [NCIt concept]
- Anti-PSMA Monoclonal Antibody-MMAE Conjugate [NCIt concept]
- Anti-PSMA/Anti-CD28 Bispecific Antibody JNJ-87189401 [NCIt concept]
- Anti-PSMA/Anti-CD3 T-cell Engaging Bispecific Antibody TNB-585 [NCIt concept]
- Anti-PSMA/Anti-CD70 4SCAR-expressing Bispecific T-cells [NCIt concept]
- Anti-PSMA/CD3 Bispecific Antibody CCW702 [NCIt concept]
- Anti-PSMA/CD3 Bispecific Antibody REGN4336 [NCIt concept]
- Anti-PSMA/CD3 Monoclonal Antibody MOR209/ES414 [NCIt concept]
- Anti-PSMA/CD3 Protease-activated T-cell Engager JANX007 [NCIt concept]
- Anti-PSMA/PBD ADC MEDI3726 [NCIt concept]
- Autologous Anti-GD2/Anti-PSMA 4SCAR-expressing Bispecific T-cells [NCIt concept]
- Autologous Anti-PSMA CAR-T Cells P-PSMA-101 [NCIt concept]
- Autologous Anti-PSMA CAR/CD2/dnTGF-BRII/PD-1:CD28 Switch Receptor-expressing T-cells TmPSMA-02 [NCIt concept]
- Autologous Anti-PSMA Gene-Modified T-Lymphocytes [NCIt concept]
- Autologous PSMA-4SCAR-expressing T-cells 4SCAR-PSMA [NCIt concept]
- Autologous PSMA-specific TGFb-resistant CAR T Cells [NCIt concept]
- CD137/PSMA/HSA Trispecific-targeting Agent CB 307 [NCIt concept]
- Copper Cu 64 NOTA-PSMAi-PEG-Cy5.5-C' Dots [NCIt concept]
- Copper Cu 64 SAR-bisPSMA [NCIt concept]
- Copper Cu 64-DOTA-TLX592 [NCIt concept]
- Copper Cu 64-PSMA-I&T [NCIt concept]
- Copper Cu 67 SAR-bisPSMA [NCIt concept]
- DNA Plasmid-encoding Interleukin-12 INO-9012/PSA/PSMA DNA Plasmids INO-5150 Formulation INO-5151 [NCIt concept]
- DNA Vector pPRA-PSM Vaccine [NCIt concept]
- Flotufolastat F-18 Gallium [NCIt concept]
- Fluorine F 18 DCFBC [NCIt concept]
- Fluorine F 18 Florastamin [NCIt concept]
- Fluorine F 18 PSMA-1007 [NCIt concept]
- Gallium Ga 68 Gozetotide [NCIt concept]
- Gallium Ga 68 PSMA-R2 [NCIt concept]
- Gallium Ga 68 labeled PSMA-targeting Radiodiagnostic Agent HRS-9815 [NCIt concept]
- Gallium Ga 68-P16-093 [NCIt concept]
- Gallium Ga 68-PSMA-617 [NCIt concept]
- Gallium Ga-labeled PSMA-11-Gadoxetate [NCIt concept]
- Gozetotide [NCIt concept]
- Indium In 111 Capromab Pendetide [NCIt concept]
- Indium In 111 Monoclonal Antibody HuJ591 [NCIt concept]
- Iodine I 131 MIP-1095 [NCIt concept]
- Iodine I-123 MIP-1095 [NCIt concept]
- Iofolastat I123 [NCIt concept]
- Lutetium Lu 177 DOTA-N3-CTT1403 [NCIt concept]
- Lutetium Lu 177 EB-PSMA-617 [NCIt concept]
- Lutetium Lu 177 Ludotadipep [NCIt concept]
- Lutetium Lu 177 PSMA-10.1 [NCIt concept]
- Lutetium Lu 177 PSMA-EB-01 [NCIt concept]
- Lutetium Lu 177 Rosopatamab Tetraxetan [NCIt concept]
- Lutetium Lu 177 Vipivotide Tetraxetan [NCIt concept]
- Lutetium Lu 177-PSMA-I&T [NCIt concept]
- Lutetium Lu-177 PNT2002 [NCIt concept]
- Lutetium Lu-177 PSMA-R2 [NCIt concept]
- Mipsagargin [NCIt concept]
- Nezastomig [NCIt concept]
- PSA/PSMA DNA Plasmid INO-5150 [NCIt concept]
- PSA/PSMA/PSCA-encoding DNA Plasmid Vaccine PF-06755990 [NCIt concept]
- PSMA-specific Targeting Module TMpPSMA [NCIt concept]
- PSMA-targeted Docetaxel Nanoparticles BIND-014 [NCIt concept]
- PSMA-targeted Tubulysin B-containing Conjugate EC1169 [NCIt concept]
- PSMA-targeting Agent-Technetium Tc99m EC0652 [NCIt concept]
- PSMA-targeting Fluorescent Imaging Agent IS-002 [NCIt concept]
- PSMA-targeting Fluorescent Imaging Agent MDX1201-A488 [NCIt concept]
- PSMA-targeting T-cell Redirecting Agent JNJ-80038114 [NCIt concept]
- PSMA/CD3 Tri-specific T-cell Activating Construct HPN424 [NCIt concept]
- PSMA/TARP Peptide Vaccine [NCIt concept]
- Recombinant Vaccinia-PSA/PSMA [NCIt concept]
- Synthetic Peptides E-PRA And E-PSM Vaccine [NCIt concept]
- Technetium Tc 99m Trofolastat [NCIt concept]
- Thorium Th 227 Pelgifatamab Corixetan [NCIt concept]
- Vidoflufolastat (18F) [NCIt concept]
- Voxalatamab [NCIt concept]
- WT1/PSMA/hTERT-encoding Plasmid DNA INO-5401 [NCIt concept]
- Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591 [NCIt concept]
- Zirconium Zr 89 Df-IAB2M [NCIt concept]
- rF-PSA/PSMA/TRICOM [NCIt concept]
- rMVA-PSA/PSMA/TRICOM [NCIt concept]

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