Preferred Label : Lutetium Lu 177 NYM032;
NCIt synonyms : 177Lu-labeled NYM032; Lutetium Lu 177 NY 108; 177Lu-NY108; 177Lu-NYM032;
NCIt definition : A radioconjugate composed of NYM032, a human prostate-specific membrane antigen (PSMA)-targeting
ligand, conjugated to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with
potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous
administration, lutetium Lu 177 NYM032 targets and binds to PSMA-expressing tumor
cells. Upon binding, PSMA-expressing tumor cells are destroyed by direct cytotoxicity
through beta radiation. PSMA, a tumor-associated antigen (TAA) and type II transmembrane
protein, is expressed on the membrane of prostatic epithelial cells and overexpressed
on prostate tumor cells as well as a variety of other solid tumors.;
Origin ID : C216090;
concept_is_in_subset
- has_target
