NCIt synonyms : Thorium-227 Labeled Immunoconjugate BAY-2315497; Targeted Thorium Conjugate BAY 2315497; Th 227 Anti-PSMA Monoclonal Antibody BAY 2315497; PSMA-targeted Thorium-227 Conjugate BAY-2315497; Thorium-227 Labeled Antibody-chelator Conjugate BAY 2315497; PSMA-TTC BAY 2315497; Thorium Th 227 Monoclonal Antibody BAY 2315497; Thorium-227 Anti-PSMA Monoclonal Antibody BAY 2315497; 227Th-Pelgifatamab Corixetan;
NCIt definition : A radioimmunoconjugate consisting of pelgifatamab, a monoclonal antibody targeting
the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA),
conjugated to the chelator corixetan, and labeled with the alpha-emitting radioisotope
thorium Th 227, with potential antineoplastic activity. Upon administration of thorium
Th 227 pelgifatamab corixetan, the pelgifatamab moiety targets and specifically binds
to PSMA on tumor cells, thereby delivering a cytotoxic dose of alpha radiation to
cells expressing PSMA. PSMA is overexpressed on the surface of metastatic and hormone-refractory
prostate cancer cells.;
Semantic type(s)