NCIt synonyms : Autologous Anti-PSMA CAR T-cells P-PSMA-101; Autologous Anti-PSMA CAR T Cells P-PSMA-101;
NCIt definition : A preparation of autologous T-cells that are enriched to be primarily stem memory
T-cells (Tscm) and are transfected by electroporation with a proprietary transposon-based
DNA plasmid vector (PiggyBac), encoding both a chimeric antigen receptor (CAR) based
on a proprietary non-immunoglobulin scaffold molecule Centyrin (CARTyrin), which specifically
recognizes the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA),
and a human-derived safety switch that can be activated by rimiducid, with potential
immunostimulating and antineoplastic activities. Upon administration, autologous anti-PSMA
CAR-T cells P-PSMA-101 specifically recognize and induce selective toxicity in PSMA-expressing
tumor cells. Use of CARTyrin may elicit less immunotoxicity than CAR T-cells based
on antibody-derived single chain variable fragments (scFv), and may allow for increased
persistence and decreased exhaustion for the administered T-cells. If significant
side effects occur, the safety switch mechanism can be activated by the administration
of rimiducid, which results in the rapid attenuation or elimination of P-PSMA-101.
PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate
cancer cells.;