Preferred Label : PSMA-targeting Fluorescent Imaging Agent MDX1201-A488;
NCIt definition : A recombinant, human monoclonal antibody targeting an extracellular epitope of human
prostate specific membrane antigen (PSMA) that is conjugated with A488, a photostable
fluorescent dye with a high quantum yield, with potential imaging activity. Upon intravenous
administration of PSMA-targeting fluorescent imaging agent MDX1201-A488, the MDX1201
moiety targets PSMA expressed on cancer cells. Subsequently, the A488 moiety can then
be visualized by fluorescence-based imaging and the amount of PSMA-expressing tumor
cells can be assessed. PSMA, a tumor-associated antigen and type II transmembrane
protein, is expressed on the membrane of prostatic epithelial cells and overexpressed
on prostate tumor cells.;
Molecule name : MDX1201-A488;
NCI Metathesaurus CUI : CL458233;
Origin ID : C113439;
UMLS CUI : C3827102;
Semantic type(s)
- concept_is_in_subset
- has_target
