NCIt definition : An anti-prostate specific membrane antigen (PSMA)/anti-CD3 bispecific humanized monoclonal
antibody, with potential immunostimulatory and antineoplastic activities. Anti-PSMA/CD3
monoclonal antibody MOR209/ES414 possesses two antigen-recognition sites, one for
the CD3 complex, a group of T-cell surface glycoproteins that complex with the T-cell
receptor (TCR), and one for PSMA, a tumor-associated antigen (TAA) overexpressed on
the surface of prostate tumor cells. Upon intravenous administration of MOR209/ES414,
this bispecific antibody simultaneously binds to both CD3-expressing T-cells and PSMA-expressing
cancer cells, thereby crosslinking PSMA-expressing tumor cells and cytotoxic T-lymphocytes
(CTLs). This results in CTL-mediated cancer cell lysis of prostate cancer cells expressing
PSMA.;
Semantic type(s)