NCIt definition : A bispecific gamma delta T-cell engager (TCE) antibody targeting both the tumor-associated
antigen (TAA) human prostate-specific membrane antigen (PSMA) and Vdelta2 on Vgamma9Vdelta2
T-cells, with potential immunostimulating and antineoplastic activities. Upon administration,
anti-PSMA gamma delta T-cell engaging bispecific antibody LAVA-1207 binds to both
PSMA-expressing tumor cells and Vgamma9Vdelta2 T-cells. This activates and redirects
the Vgamma9Vdelta2 T-cells to PSMA-expressing tumor cells, and the Vgamma9Vdelta2
T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells.
In addition, the Vgamma9Vdelta2 T-cells activate the immune system to exert a cytotoxic
T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a
key role in the activation of the immune system and do not require major histocompatibility
complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The Vdelta2
gamma delta T-cell subset is one of the two major gamma delta T-cell subsets that
is almost exclusively paired with the Vgamma9 chain. PSMA, a type II transmembrane
protein, is expressed on the membrane of prostatic epithelial cells and overexpressed
on prostate tumor cells as well as a variety of other solid tumors.;
Semantic type(s)