AdC68 Expressing PSA/PSMA/PSCA Vaccine PF-06755992

Preferred Label : AdC68 Expressing PSA/PSMA/PSCA Vaccine PF-06755992;

NCIt synonyms : Chimpanzee Adenovirus Serotype-68 Expressing PSA/PSMA/PSCA Priming Vaccine PF-06755992;

NCIt definition : A prime cancer vaccine comprised of a genetically engineered, replication-deficient chimpanzee adenovirus serotype-68 (AdC68) encoding the tumor-associated antigens (TAAs) human prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) and prostate stem cell antigen (PSCA), with potential immunostimulating and antineoplastic activities. Upon administration of AdC68 expressing PSA/PSMA/PSCA priming vaccine PF-06755992, the adenovirus infects and expresses PSA, PSMA and PSCA. The expressed proteins may stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing PSA, PSMA and PSCA, thereby inducing tumor cell lysis. PSA, PSMA and PSCA are overexpressed on a variety of cancer cell types.;

Molecule name : PF-06755992; PF 06755992;

NCI Metathesaurus CUI : CL1664854;

Details

Origin ID

C181900;

UMLS CUI

C4733488;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Glutamate Carboxypeptidase 2 [NCIt concept]
- Prostate Stem Cell Antigen [NCIt concept]
- Prostate-Specific Antigen [NCIt concept]

Keyword's position in hierarchy(ies) :

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