Prostate Stem Cell Antigen

Preferred Label : Prostate Stem Cell Antigen;

NCIt synonyms : Prostate Stem Cell Antigen Protein; Prostate Antigen; PSCA; PSCA Protein;

NCIt definition : Prostate stem cell antigen (123 aa, 13 kDa) is encoded by the human PSCA gene. This protein may play a role in the regulation of cell proliferation.;

NCIt note : Prostate stem cell antigen is a glycosylphosphatidylinositol (GPI)-linked cell surface antigen whose expression in prostate cancer is directly correlated with disease severity, and inversely correlated with prognosis. This protein has been utilized as a biomarker for bladder, prostate, and pancreatic cancers.;

Details

Origin ID

C50887;

UMLS CUI

C1612119;

Automatic exact mappings (from CISMeF team)
- Prostate stem cell antigen [OMIM gene]
- prostate stem cell antigen [HGNC gene]
OMIM relation
- Prostate stem cell antigen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- PSCA protein, human [MeSH concept]
- PSCA protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- PSCA Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Outer Leaflet of the Lipid Bilayer [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
is_target
- AdC68 Expressing PSA/PSMA/PSCA Vaccine PF-06755992 [NCIt concept]
- Anti-PSCA Monoclonal Antibody AGS-1C4D4 [NCIt concept]
- Autologous Anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T-lymphocytes [NCIt concept]
- Autologous Retroviral Vector MSGV1-transduced Anti-PSCA-8T28Z CAR Gamma Delta T-cells [NCIt concept]
- Iodine I 124-labeled Anti-PSCA A11 Minibody [NCIt concept]
- PSA/PSMA/PSCA-encoding DNA Plasmid Vaccine PF-06755990 [NCIt concept]

Keyword's position in hierarchy(ies) :

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