Preferred Label : Iodine I 124-labeled Anti-PSCA A11 Minibody;
NCIt synonyms : 124I-A11 PSCA Minibody;
NCIt definition : A radioconjugate composed of an affinity-matured antibody fragment, the A11 minibody,
directed against human prostate stem cell antigen (PSCA), and conjugated with the
radioisotope iodine I 124, that can potentially be used as an imaging agent for positron
emission tomography (PET)/computed tomography (CT). The minibody moiety of iodine
I 124-labeled anti-PSCA A11 minibody selectively targets and binds to PSCA. The PSCA-expressing
tumor cells can then be visualized using PET/CT. PSCA, a cell surface antigen expressed
in normal human prostate and bladder, is overexpressed in a variety of cancers, including
bladder, pancreatic, and prostate cancer. The A11 minibody is formed by the fusion
of a single chain Fv fragment with the immunoglobulin G1 CH3 domain.;
NCI Metathesaurus CUI : CL472326;
Origin ID : C114501;
UMLS CUI : C3898666;
Semantic type(s)
- concept_is_in_subset
- has_target
