Autologous Retroviral Vector MSGV1-transduced Anti-PSCA-8T28Z CAR Gamma Delta T-cells

Preferred Label : Autologous Retroviral Vector MSGV1-transduced Anti-PSCA-8T28Z CAR Gamma Delta T-cells;

NCIt synonyms : Genetically-modified Gamma-retroviral MSGV1-PSCA-8T28Z CAR Autologous Gamma Delta T-lymphocytes; MSGV1-PSCA-8T28Z specific CAR-transduced Autologous Gamma Delta T Lymphocytes; Autologous MSGV1-PSCA-8T28Z gdCAR T-cells; MSGv1-PSCA-8T28Z CAR Autologous gdT-cells;

NCIt definition : A preparation of autologous gamma, delta T-lymphocytes transduced with the gamma retroviral vector MSGV1 expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) prostate stem cell antigen (PSCA), and expressing a hinge/transmembrane domain derived from CD8alpha (CD8a) and a single co-stimulatory domain derived from CD28 (8t28z), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous retroviral vector MSGV1-transduced anti-PSCA-8T28Z CAR gamma delta T-cells specifically target, bind to and kill tumor cells expressing PSCA. PSCA is a glycosyl-phosphatidylinositol (GPI)-linked cell surface antigen found in various cancers.;

NCI Metathesaurus CUI : CL1926300;

Details

Origin ID

C204025;

UMLS CUI

C5909548;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Prostate Stem Cell Antigen [NCIt concept]

Keyword's position in hierarchy(ies) :

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