NCIt definition : A proprietary preparation of polymeric nanoparticles containing the second-generation
taxane docetaxel, targeted to prostate-specific membrane antigen (PSMA), with antineoplastic
activity. PSMA-targeted docetaxel nanoparticles BIND-014 carry docetaxel within a
matrix of polylactic acid covered with a coating of polyethylene glycol; embedded
on the surface of the polyethylene glycol coating are ligands targeted to PSMA. BIND-014
allows gradual release of docetaxel upon degradation of the polylactic acid, and the
PEG encapsulation escapes the host immune response while PSMA ligands on the surface
restrict the cytotoxic effect to PSMA-expressing cells. Docetaxel binds to and stabilizes
the beta-tubulin subunit, thereby inhibiting microtubule disassembly which results
in cell-cycle arrest at the G2/M phase and cell death. PSMA is a cell-surface antigen
that is abundantly present on the surface of cancer cells and on the neovasculature
that feeds a wide variety of tumor types.;
Semantic type(s)