Preferred Label : Actinium Ac 225-FL-020;
NCIt synonyms : [225Ac]Ac-FL-020; [225Ac]-FL-020; Actinium Ac 225-labeled FL-020; Actinium Ac 225 FL-020;
NCIt definition : A radioconjugate composed of FL-020, a human prostate-specific membrane antigen (PSMA)-targeting
ligand, conjugated to the alpha-emitting radioisotope actinium Ac 225, with potential
antineoplastic activity. Upon administration of actinium Ac 225-FL-020, FL-020 targets
and binds to PSMA-expressing tumor cells. Upon binding, the radioisotope moiety delivers
a cytotoxic dose of alpha radiation to PSMA-expressing tumor cells. PSMA, a tumor-associated
antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on prostate tumor cells as well as a variety of
other solid tumors.;
Origin ID : C212902;
concept_is_in_subset
- has_target
