Preferred Label : Anti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704;
NCIt related terms : MLN2704; MLN591DM1;
NCIt definition : An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed
against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal
antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane
antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid
moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly,
resulting in a disruption of microtubule activity and cell division, and cell death.
(NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of prostate cancer.
It belongs to the family of drugs called antibody drug conjugates.;
Molecule name : MLN591DM1;
Codes from synonyms : CDR0000513008; CDR0000306508;
Origin ID : C26660;
UMLS CUI : C4759828;
Semantic type(s)
- concept_is_in_subset
- has_target
