Preferred Label : WT1/PSMA/hTERT-encoding Plasmid DNA INO-5401;
NCIt definition : A preparation composed of three separate DNA plasmids encoding the tumor-associated
antigens (TAAs) Wilms tumor gene-1 (WT1), prostate-specific membrane antigen (PSMA)
and human telomerase reverse transcriptase (hTERT), with potential immunostimulating
and antineoplastic activites. Upon intramuscular delivery and electroporation of the
WT1/PSMA/hTERT-encoding plasmid DNA INO-5401, the genes are translated into their
respective proteins inside the cell. The expressed proteins activate the immune system
and induce a cytotoxic T-lymphocyte (CTL)-mediated response against cells expressing
the WT1, PSMA and hTERT antigens, causing tumor cell lysis. hTERT, WT1 and PSMA are
upregulated in many cancer cell types.;
Molecule name : INO-5401; INO 5401;
NCI Metathesaurus CUI : CL551059;
Origin ID : C148480;
UMLS CUI : C4725065;
Semantic type(s)
- concept_is_in_subset
- has_target
