Preferred Label : PSMA-targeted Tubulysin B-containing Conjugate EC1169;
NCIt definition : An injectable, water soluble, small molecule drug conjugate (SMDC) containing a ligand
specific for prostate-specific membrane antigen (PSMA), conjugated via a stable, enzyme-cleavable
linker to the cytotoxic agent tubulysin B hydrazide (TubBH), with potential antineoplastic
activity. Upon administration of PSMA-targeted tubulysin B-containing conjugate EC1169,
the PSMA ligand specifically targets and binds to PSMA, a protein which is abundantly
expressed on the surface of metastatic and hormone-refractory prostate cancer cells
as well as on the neovasculature of many solid tumors. This allows for the specific
delivery of TubBH to PSMA-expressing cancer cells. Upon internalization and cleavage,
tubulysin B binds to tubulin and inhibits microtubule polymerization, which blocks
cell division and results in G2/M phase arrest, tumor cell apoptosis and a decrease
in PSMA-expressing tumor cells.;
Molecule name : EC1169; EC1719;
NCI Metathesaurus CUI : CL474117;
Origin ID : C117291;
UMLS CUI : C3896864;
Semantic type(s)
- concept_is_in_subset
- has_target
