Preferred Label : Lutetium Lu 177 Zadavotide Guraxetan;
NCIt synonyms : Zadavotide Guraxetan Lutetium Lu-177; [Lu-177]-PSMA-I and T; Lutetium Lu 177 PSMA I&T; Lutetium Lu 177-PSMA-I&T; 177Lu-labeled PNT2002; Lutetium Lu-177-PNT2002; [Lu-177]-PNT2002; Lu177-PNT2002; 177Lu-labeled PSMA I&T; 177Lu-PNT2002; Lu-177-PSMA-I&T; Lutetium Lu-177 PNT2002;
NCIt related terms : LUTETIUM LU-177 ZADAVOTIDE GURAXETAN;
NCIt definition : A radioconjugate composed of zadavotide guraxetan, a human prostate-specific membrane
antigen (PSMA)-targeting ligand, conjugated to the beta-emitting radioisotope lutetium
Lu 177 (177Lu), with potential antineoplastic activity. Upon administration of lutetium
Lu-177 zadavotide guraxetan, the zadavotide guraxetan moiety targets and binds to
PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed
by 177Lu through the specific delivery of beta particle radiation. PSMA, a tumor-associated
antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on the majority of prostate tumor cells.;
UNII : G5B860B0G1;
CAS number : 2447131-70-4;
NCI Metathesaurus CUI : CL1773032; CL1793922;
Origin ID : C184831;
UMLS CUI : C5669569;
Semantic type(s)
- concept_is_in_subset
- has_target
