Preferred Label : PSMA-targeting T-cell Redirecting Agent JNJ-80038114;
NCIt synonyms : PSMA-targeted T-cell Redirecting Agent JNJ-80038114;
NCIt definition : An agent that targets the tumor-associated antigen (TAA) human prostate-specific membrane
antigen (PSMA) and redirects T-cells to PSMA-expressing tumor cells, with potential
antineoplastic activity. Although the mechanism of action has not been elucidated,
upon administration, PSMA-targeting T-cell redirecting agent JNJ-80038114 targets
PSMA found on PSMA-expressing tumor cells, and redirects T-cells to the PSMA-expressing
tumor cells. This may result in T-cell-mediated cell death of PSMA-expressing tumor
cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on prostate tumor cells as well as a variety of
other solid tumors.;
Molecule name : JNJ 80038114; JNJ-80038114;
NCI Metathesaurus CUI : CL1794276;
Origin ID : C189048;
UMLS CUI : C5706525;
Semantic type(s)
- concept_is_in_subset
- has_target
