Preferred Label : Actinium Ac 225-PSMA-Trillium;
NCIt synonyms : 225Ac-PSMA-Trillium; 225Ac-labeled PSMA-Trillium;
NCIt definition : A radioconjugate composed of PSMA-trillium, a human prostate-specific membrane antigen
(PSMA)-targeting small molecule that is linked to an albumin-binding moiety, and conjugated
to the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic
activity. Upon administration, actinium Ac 225-PSMA-trillium targets and binds to
PSMA-expressing tumor cells. Upon binding, the radioisotope moiety delivers a cytotoxic
dose of alpha radiation to PSMA-expressing tumor cells. PSMA, a tumor-associated antigen
(TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on prostate tumor cells as well as a variety of
other solid tumors. The albumin-binding moiety targets and binds to albumin, which
may improve therapeutic efficacy and reduce side effects in normal organs.;
Molecule name : BAY 3563254; BAY-3563254;
NCI Metathesaurus CUI : CL1928603;
Origin ID : C206261;
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