NCIt definition : A radioconjugate composed of an urea-based human prostate-specific membrane antigen
(PSMA)-targeting ligand, conjugated to the gamma-emitting radioisotope technetium
Tc 99m, with potential use as a tracer for PSMA-expressing tumors using single photon
emission computed tomography/computed tomography (SPECT/CT). Upon intravenous administration
of the technetium Tc 99m trofolastat, the trofolastat moiety targets and binds to
PSMA-expressing tumor cells. Upon internalization, PSMA-expressing tumor cells can
be detected during SPECT/CT imaging. PSMA, a tumor-associated antigen and type II
transmembrane protein, is expressed on the membrane of prostatic epithelial cells
and overexpressed on prostate tumor cells.;
CAS number : 1660954-70-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1660954-70-0
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Automatic exact mappings (from CISMeF team)
