Preferred Label : PSA/PSMA DNA Plasmid INO-5150;
NCIt synonyms : PSA/PSMA-encoding DNA Plasmid INO-5150; PSA/PSMA Synthetic DNA Vaccine INO-5150;
NCIt definition : A plasmid DNA vaccine encoding the tumor-associated antigens (TAAs) prostate-specific
antigen (PSA) and prostate-specific membrane antigen (PSMA), with potential immunoactivating
and antineoplastic activities. Upon intramuscular delivery and electroporation of
the PSA/PSMA DNA plasmid INO-5150, both PSA and PSMA are translated in cells which
then activate the immune system. This induces cytotoxic T-lymphocyte (CTL) responses
against tumor cells expressing PSA and PSMA. This may result in both immune-mediated
tumor cell death and the inhibition of tumor cell proliferation. PSA and PSMA are
overexpressed on a variety of cancer cell types. The DNA encoding the TAAs in INO-5150
is based on both human and other primate antigen gene sequences. As the plasmid genes
differ from the human gene sequences encoding these antigens, INO-5150 may overcome
immune tolerance to human TAAs.;
Molecule name : INO-5150; INO 5150;
Origin ID : C123283;
UMLS CUI : C4053631;
Semantic type(s)
- concept_is_in_subset
- has_target
