NCIt synonyms : PSMA X CD3 Bispecific Antibody REGN4336;
NCIt definition : A bispecific antibody that targets both the tumor-associated antigen (TAA) human prostate-specific
membrane antigen (PSMA) and the CD3 antigen found on T-lymphocytes, with potential
immunostimulatory and antineoplastic activities. Upon administration of anti-PSMA/CD3
bispecific antibody REGN4336, this bispecific antibody binds to both CD3 on cytotoxic
T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates
and redirects CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated
cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of
metastatic and hormone-refractory prostate cancer cells.;
Semantic type(s)