Preferred Label : Flotufolastat F-18 Gallium;
NCIt synonyms : rhPSMA-7.3 (18F); Fluorine-18 rhPSMA-7.3; (18F)-rhPSMA-7.3; 18FrhPSMA-7.3; F-18-rhPSMA-7.3; Fluorine F 18 Radiohybrid PSMA-7.3; 18F-rhPSMA-7.3; Fluorine F 18 rhPSMA-7.3;
NCIt related terms : Posluma;
NCIt definition : A radiohybrid prostate specific membrane antigen (rhPSMA) ligand, rhPSMA-7.3, labeled,
via the bifunctional, macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1-(glutamic
acid)-4,7,10-triacetic acid (DOTAGA; DOTA-GA) in complex with nonradioactive gallium,
with the radioisotope fluorine F 18, which is covalently bound to silicon, with potential
imaging activity using positron emission tomography/computed tomography (PET/CT) or
positron emission tomography/magnetic resonance imaging (PET/MRI). Upon administration
of flotufolastat F-18 gallium, the rhPSMA-7.3 moiety targets and binds to PSMA-expressing
tumor cells. This allows for visualization of PSMA-expressing cells upon imaging.
PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed
on the membrane of prostatic epithelial cells and strongly overexpressed in prostate
cancer (PCa) cells, with its level rising with increasing tumor differentiation and
in hormone-refractory cancers.;
UNII : XD423NK2WO;
CAS number : 2305081-64-3;
Drug name : Posluma;
NCI Metathesaurus CUI : CL1378660;
Origin ID : C168738;
UMLS CUI : C5783385;
CISMeF manual mappings
- Semantic type(s)
- concept_is_in_subset
- has_target
