Preferred Label : DNA Plasmid-encoding Interleukin-12 INO-9012/PSA/PSMA DNA Plasmids INO-5150 Formulation
INO-5151;
NCIt synonyms : INO-5150 with INO-9012; Formulation INO-5150 with INO-9012; INO-5150/INO-9012 Formulation;
NCIt definition : A DNA-based combined formulation composed of INO-5150, DNA plasmids encoding the tumor-associated
antigens (TAAs) prostate-specific antigen (PSA) and prostate-specific membrane antigen
(PSMA), and INO-9012, a plasmid DNA vaccine encoding the immune activator and pro-inflammatory
cytokine human interleukin-12 (IL-12), with potential immunoactivating and antineoplastic
activities. Upon intramuscular delivery of INO-5151 and electroporation of the PSA/PSMA
DNA plasmid INO-5150, PSA and PSMA are translated in cells and elicit a cytotoxic
T-lymphocyte (CTL) response against cancer cells expressing PSA and PSMA, resulting
in tumor cell lysis. Upon electroporation of the DNA plasmid encoding IL-12 INO-9012,
IL-12 is translated in cells and the expressed IL-12 activates the immune system by
promoting the activation of natural killer cells (NK cells), inducing secretion of
interferon-gamma (IFN-g) and promoting CTL responses against tumor cells. This boosts
the immune response and results in increased CTL-mediated tumor cell death as compared
with the administration of INO-5150 alone. PSA and PSMA are overexpressed on a variety
of cancer cell types.;
Molecule name : INO 5151; INO-5151;
NCI Metathesaurus CUI : CL977247;
Origin ID : C163978;
UMLS CUI : C5235866;
Semantic type(s)
- concept_is_in_subset
- has_target
