Preferred Label : Lutetium Lu 177 PSMA-10.1;
NCIt synonyms : 177Lu-rhPSMA-10.1; (177Lu) rhPSMA-10.1; 177Lu rhPSMA-10.1; 177Lu Radiohybrid PSMA-10.1;
NCIt definition : A radioconjugate composed of PSMA-10.1, a prostate-specific membrane antigen (PSMA)-targeting
ligand and radiolabeled with the beta-emitting radioisotope lutetium Lu 177 (177Lu),
with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous
administration of lutetium Lu 177 PSMA-10.1, PSMA-10.1 targets and binds to PSMA-expressing
tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through
the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen
(TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on prostate tumor cells as well as a variety of
other solid tumors.;
NCI Metathesaurus CUI : CL1793070;
Origin ID : C188236;
UMLS CUI : C5707677;
Semantic type(s)
- concept_is_in_subset
- has_target
