Preferred Label : Lutetium Lu 177 Tezuvotide Tetraxetan;
NCIt synonyms : 177Lu-rhPSMA-10.1; (177Lu) rhPSMA-10.1; 177Lu rhPSMA-10.1; 177Lu Radiohybrid PSMA-10.1; Lutetium Lu 177 PSMA-10.1; Lutetium (177Lu) Tezuvotide Tetraxetan;
NCIt definition : A radioconjugate composed of PSMA-10.1, a prostate-specific membrane antigen (PSMA)-targeting
ligand and radiolabeled with the beta-emitting radioisotope lutetium Lu 177 (177Lu),
with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous
administration, lutetium Lu 177 tezuvotide tetraxetan targets and binds to PSMA-expressing
tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through
the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen
(TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on prostate tumor cells as well as a variety of
other solid tumors.;
UNII : FJ9Z7Y8MRW;
CAS number : 2613239-73-7;
NCI Metathesaurus CUI : CL1793070;
Origin ID : C188236;
UMLS CUI : C5707677;
Semantic type(s)
- concept_is_in_subset
- has_target
