Preferred Label : PSMA/CD3 Tri-specific T-cell Activating Construct HPN424;
NCIt synonyms : PSMA/CD3 TriTAC HPN424; TriTAC HPN424; PSMA/CD3-specific TriTAC HPN424; Anti-PSMA/CD3 TriTAC HPN424;
NCIt related terms : HPN-424;
NCIt definition : A recombinant antibody derivative composed of tri-specific T-cell activating construct
(TriTAC) directed against the human tumor-associated antigen (TAA) prostate-specific
membrane antigen (PSMA; FOLH1) and the CD3 antigen found on T-lymphocytes and an albumin-binding
domain, with potential immunostimulating and antineoplastic activities. Upon administration,
PSMA/CD3 tri-specific T-cell antibody construct HPN424 targets and binds PSMA on tumor
cells and CD3 on cytotoxic T-lymphocytes (CTLs), thereby bringing PSMA-expressing
tumor cells and CTLs together, which results in the CTL-mediated cell death of PSMA-expressing
tumor cells. The albumin-binding domain targets and binds to serum albumin, thereby
extending the serum half-life of HPN424. PSMA is overexpressed on the surface of metastatic
and hormone-refractory prostate tumor cells.;
UNII : ZAA5KE2UAS;
Molecule name : HPN-424; HPN 424;
NCI Metathesaurus CUI : CL935732;
Origin ID : C156681;
UMLS CUI : C4744982;
Semantic type(s)
- concept_is_in_subset
- has_target
